Preheat your oven to 375°F (190°C) and line a baking sheet with parchment paper for easy cleanup.
Cook the ground beef in a skillet over medium heat, stirring until browned and fully cooked. Drain any excess grease.
Season the beef with garlic powder, onion powder, salt, and pepper. Stir in the cream cheese and shredded cheddar cheese until the mixture is smooth and well combined. Remove from heat.
Separate the biscuit dough into individual portions and flatten each one into a circle.
Spoon the beef and cheese filling onto the center of each circle. Fold the edges of the dough over the filling and pinch them tightly to seal.
Combine the melted butter and grated Parmesan cheese in a small bowl. Brush this mixture over the tops of the sealed bombs.
Arrange the bombs on the prepared baking sheet, leaving space between each one. Bake for 12-15 minutes, or until the tops are golden brown.
Allow the bombs to cool slightly before serving. Garnish with freshly chopped parsley for a vibrant finishing touch.